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U.S. President Donald Trump has signed a new executive order launching a government-wide initiative to build an integrated artificial intelligence platform designed to leverage vast federal scientific datasets for next-generation research and innovation.
The initiative—called the Genesis Mission—aims to transform the scientific discovery process by enabling AI systems to train on extensive government datasets and generate advanced scientific foundation models. These models will support AI agents capable of testing hypotheses, automating research workflows, and dramatically shortening the time required for major breakthroughs.
Under the order, the U.S. Department of Energy (DOE) and the national laboratories will lead the effort to unify the country’s most powerful supercomputers, research capabilities, and scientific archives into a coordinated national infrastructure for AI-driven science.
DOE will be responsible for developing a closed-loop AI experimentation platform that integrates supercomputing resources, high-value federal datasets, and robotic laboratories. The goal is to allow AI systems to not only analyse data but also run experiments, generate simulations, and validate results at unprecedented speed.
Michael Kratsios, Director of the White House Office of Science and Technology Policy, said the Genesis Mission seeks to “massively accelerate the rate of scientific breakthrough” by opening federal datasets to AI systems capable of automating experiment design and producing predictive models across fields ranging from protein folding to fusion plasma behaviour. Discovery timelines that once took years could be reduced to days or even hours, he said.
Energy Secretary Chris Wright highlighted the scale of private-sector investment in AI but noted that the federal government holds unique strategic datasets essential for scientific and engineering advancements. Consolidating these resources, he said, will help redirect AI capabilities toward foundational research that supports national priorities.
The executive order places particular emphasis on applications tied to U.S. national, economic, and health security, including biotechnology, critical minerals, nuclear fission and fusion, quantum information sciences, space exploration, and semiconductor development.
Since taking office, Trump has prioritised securing U.S. leadership in the global AI race—especially in relation to China. Earlier this year, he directed his administration to develop an AI Action Plan aimed at making the United States “the world capital in artificial intelligence.” He also revoked the AI safety-focused executive order issued by former President Joe Biden, signalling a shift toward rapid innovation and reduced regulatory hurdles.
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